Joachim Jehl

This paper introduces a method to control endogenous nicotinic receptors in mice using light-activated drug release, revealing circuit-specific effects previously hidden by systemic administration.

This study shows that the interpeduncular nucleus (IPN) regulates nicotine reward by modulating VTA neuron activity through β4-containing nAChRs.

The paper shows nicotine inhibits amygdala-projecting dopamine neurons via a VTA-NAc feedback loop, leading to anxiety.

This study shows that dopamine signals in the nucleus accumbens reflect dynamic representation learning during adaptive decision-making in mice.

This study identifies distinct dopamine circuits in the ventral tegmental area that mediate nicotine's reinforcing and anxiogenic effects through opposing responses in neurons projecting to the nucleus accumbens and amygdala.