Jacob Gratten

The paper identifies genetically distinct patient subgroups across diseases by analyzing polygenic risk and pathway convergence.

This study identifies sex-dependent genetic risk loci shared and specific to mood and psychotic disorders using genome-wide interaction analysis.

This study investigates genetic correlations and causal relationships between multiple sclerosis and inflammatory bowel diseases, identifying shared SNPs and tissue-specific heritability patterns.

The paper compares ten polygenic score methods for psychiatric disorders across multiple cohorts, finding that some methods significantly improve prediction statistics over the baseline PC+T method.

Across 37,688 Parkinson's cases, 18,618 proxy-cases and 1.4M controls, 90 risk signals map to 78 loci (37 new); an 1805-variant polygenic score explains 26-36% of heritability.

This paper investigates the genetic links between female reproductive traits and six psychiatric disorders using polygenetic risk scores from UK Biobank data.

This study conducts a GWAS to identify genetic determinants of Parkinson's disease age of onset, finding associations with SNCA, TMEM175, and GBA, and highlighting alpha-synuclein's role in disease onset.

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

The paper quantifies assortative mating on complex traits by analyzing SNP data from 400,000 individuals, finding significant evidence for height and educational attainment.

The paper improves age prediction from DNA methylation using larger datasets, showing reduced error and limitations in capturing biological ageing variation.

The paper finds a genetic association between schizophrenia risk and age at first birth in women, with different genetic correlations in younger and older age groups.

This study compares LDSC and GREML methods for estimating genetic correlation, showing GREML provides higher accuracy, especially in the presence of genetic heterogeneity.

The paper identifies 91 genes associated with neurodevelopmental disorders but highlights critical statistical flaws in the analysis that reduce the validity of the findings.

The paper identifies genetic variants associated with subjective well-being, depressive symptoms, and neuroticism using genome-wide association studies and proxy-phenotype analyses.