Author
Queen Mary University of LondonORCID 0000-0003-1307-5450Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
4 papers
Recent·Most cited
Molly A Guscott, Audrey Lumeau, A. Gallagher…·Sarah Elizabeth McClelland
This study shows that chromosomal instability (CIN) drives rapid genome changes in cancer cells, generating new copy number alterations each cell cycle and increasing genomic complexity.
Jovanna Kimeera Maharaj, Isabel McNeil, Molly A Guscott…·Sarah Elizabeth McClelland
RaMN-Seq rapidly purifies and sequences micronuclei to study chromosomal instability in cancer and other contexts.
Audrey Lumeau, Pauline Luise Pfuderer, S De Angelis…·Sarah Elizabeth McClelland
This study identifies that high levels of DNA replication initiation factors correlate with ATR inhibitor sensitivity due to excessive origin firing in cancer cells.
Molly A Guscott, David Gómez-Peregrina, Alexander Malling Andersen…·Sarah Elizabeth McClelland
The paper tracks genome evolution in single-cell clones to reveal copy number alteration rates and features in cancer driven by chromosomal instability.