Author
Queen Mary University of LondonORCID 0000-0003-1797-2271Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Molly A Guscott, Audrey Lumeau, A. Gallagher…·Sarah Elizabeth McClelland
This study shows that chromosomal instability (CIN) drives rapid genome changes in cancer cells, generating new copy number alterations each cell cycle and increasing genomic complexity.
Jovanna Kimeera Maharaj, Isabel McNeil, Molly A Guscott…·Sarah Elizabeth McClelland
RaMN-Seq rapidly purifies and sequences micronuclei to study chromosomal instability in cancer and other contexts.
Audrey Lumeau, Pauline Luise Pfuderer, S De Angelis…·Sarah Elizabeth McClelland
This study identifies that high levels of DNA replication initiation factors correlate with ATR inhibitor sensitivity due to excessive origin firing in cancer cells.
Alice Mazzagatti, Nadeem Shaikh, Björn Bakker…·Sarah Elizabeth McClelland
The paper identifies DNA copy number alterations and chromosome-scale losses caused by replication stress in non-transformed cells, revealing their role in chromosomal instability and cancer evolution.