Sarah Elizabeth McClelland

Chromosomal instability drives continual flux in cancer genomes

This study shows that chromosomal instability (CIN) drives rapid genome changes in cancer cells, generating new copy number alterations each cell cycle and increasing genomic complexity.

Rapid Micronucleus-Sequencing (RaMN-Seq) Reveals Patterns of Bias in Induced and Spontaneous Chromosomal Instability

RaMN-Seq rapidly purifies and sequences micronuclei to study chromosomal instability in cancer and other contexts.

Genome-wide Chromosome-specific Aneuploidy Engineering and Phenotypic Characterization with CRISPR-Taiji

The paper introduces CRISPR-Taiji to engineer chromosome-specific aneuploidy and characterizes its transcriptomic effects, linking aneuploidy to ccRCC phenotypes.

High levels of DNA replication initiation factors indicate ATR inhibitor sensitivity via excessive origin firing

This study identifies that high levels of DNA replication initiation factors correlate with ATR inhibitor sensitivity due to excessive origin firing in cancer cells.

YAP engages RIF1 to dampen replication stress-induced DNA damage in human squamous cell carcinoma.

This study identifies YAP's interaction with RIF1 in squamous cell carcinoma, showing it reduces replication stress-induced DNA damage through non-transcriptional mechanisms.

DNA Replication Stress Generates Distinctive Landscapes of DNA Copy Number Alterations and Chromosome Scale Losses

The paper identifies DNA copy number alterations and chromosome-scale losses caused by replication stress in non-transformed cells, revealing their role in chromosomal instability and cancer evolution.