Modelling human KCNT1-epilepsy in Drosophila: a seizure phenotype and drug responses
Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat, Anowarul Islam, Emily A. Caseley, Jonathan D. Lippiat, Grigori Y. Rychkov, Michael G. Ricos, Leanne M. Dibbens
This study models human KCNT1-epilepsy in Drosophila by expressing patient mutations and shows drug responses, demonstrating the utility of Drosophila as a model for assessing treatments.
bioRxiv · Apr 11, 2023 · PreprintNeuroscience