Author

Emily A. Caseley

University of LeedsORCID 0000-0001-7591-143XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Jonathan D. LippiatiD· 2 shared Alex J. FlynniD· 1 shared Anowarul IslamiD· 1 shared Bethan A. ColeiD· 1 shared Chiao Xin LimiD· 1 shared Grigori Y. RychkoviD· 1 shared Katie J. SimmonsiD· 1 shared Leanne M. DibbensiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPharmacology & Toxicology

Jonathan D. LippiatORCID

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2 papers

Recent·Most cited

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedApr 25, 2026

Large-Scale Structure-Based Virtual Screening Identifies Diverse KNa1.1 (KCNT1) Potassium Channel Inhibitors

Emily A. Caseley, Katie J. Simmons, Bethan A. Cole…·Jonathan D. Lippiat

This study identifies eight structurally diverse KCNT1 channel inhibitors through virtual screening and experimental validation, offering potential new treatments for KCNT1-associated epilepsy.

DOI 10.1016/j.ejmech.2026.118906

humanproteomics

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NeurosciencebioRxivPreprintApr 11, 2023

Modelling human KCNT1-epilepsy in Drosophila: a seizure phenotype and drug responses

Rashid Hussain, Chiao Xin Lim, Zeeshan Shaukat…·Leanne M. Dibbens

This study models human KCNT1-epilepsy in Drosophila by expressing patient mutations and shows drug responses, demonstrating the utility of Drosophila as a model for assessing treatments.

DOI 10.1101/2023.04.11.536495

Drosophilaexperimental assay

𝕏 PostBluesky