Helena Chang Chui

This study shows cPLA2 overactivation is linked to synaptic loss and cognitive decline in Alzheimer's disease through increased eicosanoids and altered synaptic marker interactions.

This study identifies novel Alzheimer's disease risk loci by analyzing multi-ancestry GWAS data from diverse populations, highlighting the importance of including underrepresented groups in genetic research.

This study compares age-related volumetric changes in the medial temporal lobe between cognitively normal individuals and those with mild cognitive impairment, finding the rhinal cortex is less affected by aging and more indicative of Alzheimer's disease pathology.

This study identifies blood-based biomarkers associated with Alzheimer's disease genetic risk variants in a large cohort of healthy adults, showing effects from early adulthood and sex-specific patterns.

This study identifies increased circPSEN1 levels in ADAD brains compared to sporadic AD and controls, suggesting a potential role in neuroinflammatory processes.

This study identifies metabolomic and lipidomic signatures in Alzheimer's disease brains with different genetic risk factors and finds associations with disease subtypes and progression.

The paper shows that early cognitive dysfunction is associated with altered perivascular space presence and distribution, linked to tau tangle deposition in Alzheimer's disease pathology.