Author

Nicholas P. Restifo

National Institutes of HealthORCID 0000-0003-4229-4580Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alejandro A. SchäfferiD· 1 shared Binbin WangiD· 1 shared David B. ThompsoniD· 1 shared Denitsa MilanovaiD· 1 shared Di WuiD· 1 shared Eytan RuppiniD· 1 shared Ira MellmaniD· 1 shared Kun WangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Alejandro A. SchäfferORCID

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2 papers

Recent·Most cited

From prediction to engagement: defining tumor-reactive T cells through biological interaction

Nicholas P. Restifo, Suman Kumar Vodnala, David B. Thompson, Nicholas D. Klemen, Ira Mellman, Denitsa Milanova

The paper identifies tumor-reactive T cells by focusing on productive T-cell engagement with tumor cells, showing that such interactions enrich for neoantigen-reactive clonotypes with progenitor-like states.

bioRxiv · Jun 3, 2026 · PreprintImmunology

IMMClock reveals immune aging and T cell function at single-cell resolution

Yael Gurevich, Di Wu, Sanna Madan, Sanju Sinha, Sahil Sahni, Vishaka Gopalan, Binbin Wang, Saugato Rahman Dhruba, Alejandro A. Schäffer, Nan‐ping Weng, Nicholas P. Restifo, Kun Wang, Eytan Ruppin

IMMClock predicts immune age of T cells and NK cells using gene expression, showing immune aging is more linked to cellular aging than differentiation and is accelerated in diseases.

bioRxiv · Nov 13, 2024 · PreprintBioinformatics