Nucleoli as drivers of nuclear remodelling in cardiomyocytes during Heart Failure
Ingrid Matzer, Houcheng Wang, Aleksandra N. Kozyrina, JiaRong Fu, Thomas Iskratsch, Massimo Vassalli, Senka Ljubojević-Holzer, Julia Gorelik, Pamela Swiatlowska
This study investigates how nucleoli drive nuclear remodelling in cardiomyocytes during heart failure, showing NI loss precedes cytoskeletal stiffening and is linked to DNA damage and nucleolar changes.
bioRxiv · Feb 25, 2026 · PreprintCell Biology