Matthias Merker

This study shows that β-lactam resistance in Haemophilus influenzae leads to fitness costs and collateral sensitivities, with unpredictable evolutionary outcomes.

This study identifies Serratia sp. as a dominant genus in the lung microbiome of TB and NTM-LD patients, with specific ASVs associated with disease states.

The paper shows that GlnA3Mt in M. tuberculosis can glutamylate spermine but is not essential for spermine detoxification, with efflux pumps playing a compensatory role.

This study quantifies antibiotic resistance in tuberculosis using genomic data and MIC measurements to identify genetic determinants of resistance and hypersensitivity across multiple drugs.

The paper analyzes whole genome sequencing data from tuberculosis strains in Mumbai to identify factors driving the pre-XDR and XDR-TB epidemic, finding lineage 2 strains are strongly associated with these resistant forms.

GenomegaMap estimates genome-wide dN/dS ratios across 10,209 tuberculosis genomes to identify selection pressures shaping the pathogen's evolution.