Marc Vooijs

This study shows that Dmt1 deficiency disrupts iron homeostasis, leading to lysosomal dysfunction and impaired Notch signaling by affecting NICD1 degradation and transcriptional activation.

This study maps glioblastoma tumor ecosystems over time using spatial single-cell profiling to identify prognostic subgroups and treatment responses.

This study identifies compensatory pathway activation as a mechanism of resistance to single-agent small-molecule inhibitors in glioblastoma and shows that combination therapy can overcome this resistance.