Jolanda A. F. Piepers

Disruption of Iron Metabolism Resulting from Dmt1/Slc11A2 Deficiency Compromises Notch Protein Degradation and Transcriptional Activation

This study shows that Dmt1 deficiency disrupts iron homeostasis, leading to lysosomal dysfunction and impaired Notch signaling by affecting NICD1 degradation and transcriptional activation.

Adaptive Kinase Signaling Enables Escape from Small-Molecule Inhibition in Glioblastoma

This study identifies compensatory pathway activation as a mechanism of resistance to single-agent small-molecule inhibitors in glioblastoma and shows that combination therapy can overcome this resistance.