Julen Mendieta-Esteban

Diversity and evolution of chromatin regulatory states across eukaryotes

The paper profiles histone post-translational modifications across eukaryotic lineages to assess conservation of chromatin states, finding conserved euchromatin states but diverse repressive heterochromatin configurations.

Identification of epigenetic regulators of fibrotic transformation in cardiac fibroblasts through bulk and single-cell CRISPR screens

The paper identifies epigenetic regulators of fibrotic transformation in cardiac fibroblasts using bulk and single-cell CRISPR screens and shows KAT5 inhibition reduces fibrotic responses in human fibroblasts.

Probabilistic 3D-modelling of genomes and genomic domains by integrating high-throughput imaging and Hi-C using machine learning

The paper introduces pTADbit, a machine learning method that improves 3D genome modeling using Hi-C data and microscopy distances, achieving higher accuracy and faster computation.

Systematic functional screening of chromatin factors identifies strong lineage and disease dependencies in normal and malignant haematopoiesis

This study uses CRISPR screens and Perturb-Seq to analyze 550 chromatin factors in haematopoiesis and AML, revealing lineage-specific roles and therapeutic implications.

3D reconstruction of genomic regions from sparse interaction data

This paper introduces a method to reconstruct 3D chromatin organization from sparse 3C-based data, achieving reliable results with as little as 2-3% of the interaction matrix.

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes

The paper links diabetes-associated enhancers with their target genes using 3D chromatin architecture in human pancreatic islets, revealing genetic variants that impact insulin secretion heritability.