Felix Graßmann

The paper uses case-control data from over 400,000 women to classify BRCA1 and BRCA2 variants, finding high consistency with ClinVar annotations for 785 previously unclassified variants.

The paper investigates a polymorphic regulatory region in the BDNF gene associated with obesity and anxiety in mice and humans, showing altered behavior and gene expression.

The paper identifies the glucocorticoid receptor as a master regulator of Muller cell gliosis in diabetic retinopathy and shows that increasing GR expression can improve retinal function.

This study estimates mitochondrial DNA abundance in 295,150 UK Biobank participants and identifies genetic and lifestyle factors associated with it, finding links to immune aging, disease risk, and mortality.

This study performs a genome-wide association meta-analysis of early AMD, identifying 11 loci, 9 novel, and highlighting shared and distinct genetic factors between early and advanced AMD.

The paper identifies cell type-specific complement expression patterns in healthy and diseased retinas across human and murine models, highlighting age-related and disease-induced changes.