APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction
Fareeha Saadi, Yoonho Cho, Ilia V Katritch, Brisa Lugo, Yue Wu, Leon C. D. Smyth, Megan E. Bosch, Kevin Telfer, Krzysztof L. Hyrc, Samira Parhizkar, Xin Bao, Aishwarya Nambiar, Bernd H. Zinselmeyer, Song Hu, Jonathan Kipnis, , David M. Holtzman
This study shows that reducing APOE4 in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and improves vascular function in a mouse model.
bioRxiv · Oct 14, 2026 · PreprintNeuroscience