Author

Mackenzie M. Strehle

California Institute of TechnologyORCID 0000-0003-1410-8701Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Mario R. BlancoiD· 2 shared Mitchell GuttmaniD· 2 shared Abhik K. BanerjeeiD· 1 shared Alex BurriD· 1 shared Allen W CheniD· 1 shared Amy Y. ChowiD· 1 shared Benjamin L. EmertiD· 1 shared Delaney K. SullivaniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Mario R. BlancoORCID

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2 papers

Recent·Most cited

Molecular BiologyNaturePeer-reviewedMay 8, 2024

3D genome organization around nuclear speckles drives mRNA splicing efficiency

Prashant Bhat, Amy Y. Chow, Benjamin L. Emert…·Mitchell Guttman

The paper shows that gene proximity to nuclear speckles increases spliceosome binding and co-transcriptional splicing efficiency, highlighting the role of 3D genome organization in mRNA splicing.

182 citationstop 1%

humanspatial transcriptomics

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Molecular BiologybioRxivPreprintOct 27, 2021

Xist spatially amplifies SHARP recruitment to balance chromosome-wide silencing and specificity to the X chromosome

Joanna W. Jachowicz, Mackenzie M. Strehle, Abhik K. Banerjee…·Mitchell Guttman

This study shows Xist uses spatial amplification of SHARP to achieve chromosome-wide silencing while maintaining specificity to the X chromosome.

4 citations

humanexperimental assay

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