Mario R. Blanco

This paper introduces LagTag, a method to recover both earlier and endpoint chromatin states in mammalian cells, and applies it to study dynamic chromatin transitions during stem cell differentiation.

SPIDR is a high-throughput method for mapping RNA-protein interactions that identifies 4EBP1's role in selectively repressing mRNA translation under mTOR inhibition.

ChIP-DIP enables simultaneous mapping of hundreds of regulatory proteins to DNA, revealing diverse regulatory elements and their functional activity.

The paper identifies that ignoring RNA quantity in analysis leads to inflated background signals and misleading conclusions about PRC2 and GFP RNA binding.

The paper shows that gene proximity to nuclear speckles increases spliceosome binding and co-transcriptional splicing efficiency, highlighting the role of 3D genome organization in mRNA splicing.

The paper develops RD-SPRITE to map RNA-DNA and RNA-RNA interactions in 3D nuclear structures, revealing RNA's role in forming compartments that regulate nuclear functions.

This study shows Xist uses spatial amplification of SHARP to achieve chromosome-wide silencing while maintaining specificity to the X chromosome.