Joanna W. Jachowicz

Genome-wide profiling of DNA repair proteins identifies higher-order coordination in single cells

This study identifies higher-order coordination of DNA repair proteins in single cells by analyzing their genome-wide localization using DamID and ChIC sequencing.

RNA promotes the formation of spatial compartments in the nucleus

The paper develops RD-SPRITE to map RNA-DNA and RNA-RNA interactions in 3D nuclear structures, revealing RNA's role in forming compartments that regulate nuclear functions.

Xist spatially amplifies SHARP recruitment to balance chromosome-wide silencing and specificity to the X chromosome

This study shows Xist uses spatial amplification of SHARP to achieve chromosome-wide silencing while maintaining specificity to the X chromosome.

A single-cell method to map higher-order 3D genome organization in thousands of individual cells reveals structural heterogeneity in mouse ES cells