Joshua Hahn

The extreme diversity of retinal amacrine cells has deep evolutionary roots

The paper reconstructs the evolutionary origins of retinal amacrine cell diversity using transcriptomic data from 24 vertebrate species, identifying 42 orthologous cell types and suggesting a hybrid precursor origin.

EBF1 regulates sensory establishment in the cochlea by positioning the medial boundary of the prosensory domain and restricting proliferation of the sensory progenitor population

The paper uses multiome sequencing to show EBF1 regulates sensory cell development in the cochlea by setting the prosensory domain boundary and limiting progenitor proliferation.

CUT&TIME captures the history of open chromatin indeveloping neurons

The paper introduces CUT&TIME, a method to map historical chromatin accessibility in single cells during neurogenesis, revealing early changes in promoter accessibility linked to cell-fate commitment in retinal ganglion cells.

Reconfiguration of the visual code and retinal cell type complement in closely related diurnal and nocturnal mice

The paper compares retinal cell composition and visual coding between diurnal and nocturnal mice to show how evolutionary changes in cell types reconfigure visual information processing.

Ancient origin of the rod bipolar cell pathway in the vertebrate retina

The paper identifies two rod bipolar cell types in zebrafish that are related to mammalian rod bipolar cells, suggesting the primary rod pathway evolved over 400 million years ago.

Evolution of neuronal cell classes and types in the vertebrate retina

The paper integrates single-cell transcriptomic data from 17 vertebrate species to study the evolution of retinal cell types, finding conserved cell classes and subclasses with variation increasing from outer to inner retina.

Molecular classification of zebrafish retinal ganglion cells links genes to cell types to behavior

The paper classifies zebrafish retinal ganglion cells using single-cell transcriptomics, identifies marker genes, and links molecular profiles to functional behaviors.