Anders Nelson

The paper generates and characterizes knock-in mouse lines for precise genetic targeting of striatal and dopaminergic neurons, confirming their utility for studying neural circuits and disorders.

The paper identifies corticothalamic neurons in the motor cortex as having a permissive role in motor execution by suppressing inhibition of corticospinal neurons during movement.

The paper maps the connectivity of rostral and caudal forelimb corticospinal neurons to spinal cell types, showing similar targets with notable differences in influence on behavior.

The paper shows corticospinal neurons relay both kinematic-related and unrelated motor signals to distinct striatal and spinal pathways through biased innervation strategies.