Akira Fushiki

This study shows how reinforcement learning modifies specific dendritic activity through synaptic plasticity, leading to the formation of task-relevant synaptic ensembles.

The paper generates and characterizes knock-in mouse lines for precise genetic targeting of striatal and dopaminergic neurons, confirming their utility for studying neural circuits and disorders.

The paper identifies a specific subtype of dopaminergic neurons, Anxa1+, that are selectively lost in Parkinson's disease and contribute to early motor symptoms.

The paper maps the synaptic-resolution connectome of a Drosophila larva brain, identifying neuron types, circuit motifs, and structural features.

The paper maps convergence neurons in Drosophila that integrate innate and learned olfactory drives to mediate action selection.

The paper identifies an amygdala circuit that mediates experience-dependent momentary exploratory arrests in mice without affecting place preference or anxiety-like behaviors.

The paper maps the synaptic connectome of the Drosophila larva mushroom body and identifies feedback pathways that enable modulatory neurons to compute teaching signals for reinforcement learning.