Author

Ambrocio Sanchez

University of California, IrvineORCID 0000-0003-1462-1767Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Elodie BourniqueiD· 2 shared Gisselle SantiagoiD· 2 shared Junyi LiiD· 2 shared Pedro OrtegaiD· 2 shared Rémi BuissoniD· 2 shared Abby M. GreeniD· 1 shared Alexander Nathaniel GarciaiD· 1 shared Alexis BouiniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersMolecular Biology

Elodie BourniqueORCID

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2 papers

Recent·Most cited

Molecular BiologyScience AdvancesPeer-reviewedApr 16, 2025

ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping

Pedro Ortega, Elodie Bournique, Junyi Li…·Rémi Buisson

This study identifies APOBEC3B as the enzyme responsible for ssDNA breakage during replication catastrophe induced by ATR inhibition, revealing a mechanism for PARP1 trapping and synthetic lethality with PARP inhibitors.

23 citationstop 2%

experimental assay

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MicrobiologyNature CommunicationsPeer-reviewedApr 5, 2025

Cooperative Role of PACT and ADAR1 in Preventing Aberrant PKR Activation by Self-Derived Double-Stranded RNA

Lavanya Manjunath, Gisselle Santiago, Pedro Ortega…·Rémi Buisson

The paper identifies PACT as a key inhibitor of PKR during viral infection and shows that PACT and ADAR1 cooperate to prevent aberrant PKR activation by self-dsRNAs.

24 citationstop 2%

humanexperimental assay

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