Abby M. Green

This study identifies APOBEC3B as the enzyme responsible for ssDNA breakage during replication catastrophe induced by ATR inhibition, revealing a mechanism for PARP1 trapping and synthetic lethality with PARP inhibitors.

This study shows APOBEC3A promotes ovarian cancer metastasis by altering epithelial-to-mesenchymal transition in high-grade serous ovarian cancer.

This study identifies the SMC5/6 complex as essential for genome stability in cells with active APOBEC3A, showing that its loss leads to increased DNA damage and replication stress.