PathologybioRxivPreprint
TREM2-stimulated, PDGF-dependent macrophage-fibroblast crosstalk induces beneficial plaque remodeling in clonal hematopoiesis
Wenli Liu, Chenyi Xue, Malgorzata Olszewska…·Alan R. Tall
This study shows TREM2 agonism in clonal hematopoiesis enhances fibrous cap formation via macrophage-derived PDGFB and stromal PDGFR? signaling, increasing specific fibroblast populations and reducing macrophage migration.
DOI 10.64898/2026.11.09.765508