Natalia Ochocka

This paper introduces mTopic, a topic modeling framework for analyzing multimodal molecular data across single-cell and spatial contexts, enabling identification of coherent molecular programs and cross-modality associations.

The paper studies repopulated microglia in young and old mice using scRNA-seq and other methods, finding they originate from progenitors, reconstitute functional clusters, and show increased inflammation and distinct morphology in aging.

The paper uses scRNA-seq to analyze zebrafish heart development, identifying 18 cell populations and two genes critical for pacemaker function and heart rate regulation.