Sònia Tugues

This study identifies molecular programs in macrophages stimulated by tumor-derived cues, linking them to clinically relevant TAM states and functions.

This study identifies reprogrammed neutrophils with impaired transit mechanics as a driver of multi-organ capillary stalling after stroke, showing therapeutic potential through Fgr inhibition.

The paper identifies a novel macrophage-like population in exocrine glands sustained by ILC2-derived GM-CSF, showing conservation across species.

RIPPLET converts somatic DNA variants into gene-impact scores and pathway-perturbation profiles, outperforming multi-omic tools in identifying cancer drivers and predicting drug response without RNA data.

The paper identifies CD4 memory T cell networks that form therapy-responsive immune niches in colorectal cancer liver metastases, determining chemotherapy response.

The paper identifies plasmacytoid dendritic cells (pDCs) in tumor-draining lymph nodes as a potential biomarker for predicting response to PD-L1 blockade therapy in melanoma.

This study identifies meningeal monocyte-derived macrophages as drivers of progressive multiple sclerosis using single-cell and spatial transcriptomics.

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.