Author

Kirill S. Grushin

Yale UniversityORCID 0000-0003-1475-9758Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3

Frequent Co-Authors

James Edward RothmaniD· 3 shared Jeff ColemaniD· 3 shared Atrouli ChatterjeeiD· 2 shared Manindra BeraiD· 2 shared Ramalingam Venkat Kalyana SundaramiD· 2 shared Seong Lee· 2 shared Shyam Sundar KrishnakumariD· 2 shared Abhijith RadhakrishnaniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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3 shared papersNeuroscience

James Edward RothmanORCID

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3 papers

Recent·Most cited

NeuroscienceNature CommunicationsPeer-reviewedAug 5, 2025

Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release

Manindra Bera, Kirill S. Grushin, Ramalingam Venkat Kalyana Sundaram…·Jeremy S. Dittman

This study shows that two Munc13 oligomers are essential for vesicle docking and SNARE assembly, supporting neurotransmitter release.

14 citationstop 4%

experimental assay

𝕏 PostBluesky

NeurosciencebioRxivPreprintJun 5, 2023

Novel Roles for Diacylglycerol in Synaptic Vesicle Priming and Release Revealed by Complete Reconstitution of Core Protein Machinery

Ramalingam Venkat Kalyana Sundaram, Atrouli Chatterjee, Manindra Bera…·Shyam Sundar Krishnakumar

The paper reconstitutes core synaptic machinery to reveal DAG's role in vesicle priming and Ca2+-triggered release, showing DAG accelerates SNAREpin assembly and affects release dynamics.

4 citations

experimental assay

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedJun 3, 2019

Structural Basis for the Clamping and Ca2+ Activation of SNARE-mediated Fusion by Synaptotagmin

Kirill S. Grushin, Jing Wang, Jeff Coleman…·Shyam Sundar Krishnakumar

This paper determines the structure of the Syt1-SNARE complex on lipid membranes using cryo-electron microscopy to elucidate how Syt1 clamps and activates SNARE-mediated fusion through Ca2+ and Mg2+ dependent interactions.

55 citations

experimental assay

𝕏 PostBluesky