Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release
Manindra Bera, Kirill S. Grushin, Ramalingam Venkat Kalyana Sundaram, Jasmine Shahanoor Hinzen, Joyce Chen, Atrouli Chatterjee, Abhijith Radhakrishnan, Seong Lee, Murugesh Padmanarayana, Jeff Coleman, Frédéric Pincet, James E. Rothman, Jeremy S. Dittman
This study shows that two Munc13 oligomers are essential for vesicle docking and SNARE assembly, supporting neurotransmitter release.
Nature Communications · Aug 5, 2025Peer-reviewedNeuroscience