Author

Ramalingam Venkat Kalyana Sundaram

Yale UniversityORCID 0000-0002-0232-4186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4

Frequent Co-Authors

James Edward RothmaniD· 4 shared Jeff ColemaniD· 4 shared Frédéric PincetiD· 3 shared Manindra BeraiD· 3 shared Abhijith RadhakrishnaniD· 2 shared Atrouli ChatterjeeiD· 2 shared Feng LiiD· 2 shared Kirill S. GrushiniD· 2 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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4 shared papersNeuroscience

James Edward RothmanORCID

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4 papers

Recent·Most cited

Two successive oligomeric Munc13 assemblies scaffold vesicle docking and SNARE assembly to support neurotransmitter release

Manindra Bera, Kirill S. Grushin, Ramalingam Venkat Kalyana Sundaram, Jasmine Shahanoor Hinzen, Joyce Chen, Atrouli Chatterjee, Abhijith Radhakrishnan, Seong Lee, Murugesh Padmanarayana, Jeff Coleman, Frédéric Pincet, James E. Rothman, Jeremy S. Dittman

This study shows that two Munc13 oligomers are essential for vesicle docking and SNARE assembly, supporting neurotransmitter release.

Nature Communications · Aug 5, 2025Peer-reviewedNeuroscience

Synaptophysin Chaperones the Assembly of 12 SNAREpins under each Ready-Release Vesicle

Manindra Bera, Abhijith Radhakrishnan, Jeff Coleman, Ramalingam Venkat Kalyana Sundaram, Sathish Kumar Ramakrishnan, Frédéric Pincet, James Edward Rothman

This paper identifies Synaptophysin as a chaperone that organizes 12 SNAREpins under each synaptic vesicle through its hexamer structure and VAMP2 dimer binding.

Proceedings of the National Academy of Sciences · Oct 30, 2023Peer-reviewedNeuroscience

Novel Roles for Diacylglycerol in Synaptic Vesicle Priming and Release Revealed by Complete Reconstitution of Core Protein Machinery

Ramalingam Venkat Kalyana Sundaram, Atrouli Chatterjee, Manindra Bera, Kirill S. Grushin, Aniruddha Panda, Feng Li, Jeff Coleman, Seong Lee, Sathish Kumar Ramakrishnan, Andreas Max Ernst, Kallol Gupta, James Edward Rothman, Shyam Sundar Krishnakumar

The paper reconstitutes core synaptic machinery to reveal DAG's role in vesicle priming and Ca2+-triggered release, showing DAG accelerates SNAREpin assembly and affects release dynamics.

bioRxiv · Jun 5, 2023 · PreprintNeuroscience

Munc13 binds and recruits SNAP25 to chaperone SNARE complex assembly

Ramalingam Venkat Kalyana Sundaram, Huaizhou Jin, Feng Li, Tong Shu, Jeff Coleman, Jie Yang, Frédéric Pincet, Yongli Zhang, James Edward Rothman, Shyam Sundar Krishnakumar

The paper shows Munc13-1 directly binds SNAP25 to initiate SNARE complex assembly, using FRET and optical tweezer techniques.

FEBS Letters · Nov 22, 2020Peer-reviewedNeuroscience