Ling Chen

The paper shows that systemic memory B cells traffic to mucosal sites in the upper respiratory tract, contributing to local immunity, and that antigen-specific B cells accumulate there only during local inflammation.

This study develops an oncolytic adenovirus that activates a prodrug to enhance tumor killing and antitumor immunity through direct oncolysis, bystander effects, and systemic immune responses.

This study develops a HSV-vectored therapeutic vaccine that reactivates SIV latency and elicits immune responses, delaying viral rebound in SIV-infected macaques.

The paper demonstrates that TOPMed imputation improves the identification of rare variants associated with type 2 diabetes in Latino populations, leading to novel associations and better polygenic scores.

SEQdata-BEACON collects and analyzes BGISEQ-500 sequencing performance data to simulate yield and improve sequencing process understanding.

This study identifies rare genetic variants associated with type 2 diabetes using exome sequencing of 20,791 cases and 24,440 controls, and provides a Bayesian framework to improve variant prioritization.