Dika A. Kuljis

This study shows that training in a whisker-based task reduces PV-mediated inhibition in female mice's L2/3 pyramidal neurons, suggesting sex-specific plasticity in cortical circuits during learning.

The paper shows that learning alters neocortical somatostatin inhibition in a stimulus-reward dependent manner, specifically reducing inhibition in superficial layers of mouse somatosensory cortex.

The paper shows that during sensory learning in mice, PV inhibition in L2/3 pyramidal neurons decreases, enabling increased recurrent activity, but not in L5 neurons.

The paper develops genetically-encoded reagents for cell-type specific synapse labeling and connectivity analysis in mouse brain tissue, revealing PV inputs as the dominant inhibitory source onto L2 pyramidal neurons.