Author

Yong‐Chul Kim

Gwangju Institute of Science and TechnologyORCID 0000-0003-1520-2011Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

Adam C. OkeniD· 1 shared Andreea L. TurcuiD· 1 shared Annette NickeiD· 1 shared Antonios KolocourisiD· 1 shared Christa Elisabeth MülleriD· 1 shared Eva TzortziniiD· 1 shared Garam KimiD· 1 shared Jessica NageliD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Adam C. OkenORCID

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1 paper

Recent·Most cited

UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design

Adam C. Oken, Andreea L. Turcu, Eva Tzortzini, Kyriakos Georgiou, Jessica Nagel, Marta Barniol‐Xicota, Garam Kim, So‐Deok Lee, Annette Nicke, Yong‐Chul Kim, Christa Elisabeth Müller, Antonios Kolocouris, Santiago Vázquez, Steven Mansoor

The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.

bioRxiv · Feb 12, 2025 · PreprintBiochemistry