Guang He

This study identifies NUSAP1 mutations in primary microcephaly, showing they disrupt mitotic processes through interactions with KIF2C and AURKA phosphorylation.

PSTP predicts protein phase separation regions using transfer learning and attention, achieving 84% accuracy on PhaSePro and improving correlation coefficients over existing models.

PSMutPred predicts the impact of missense variants on phase separation using machine learning, improving the interpretation of variants of unknown significance in intrinsically disordered regions.

This study identifies CIB2 as a Ca2+ sensor in auditory mechano-electrical transduction and links TMC1 genetic variants to hearing loss through structural and functional analysis.

The paper describes a natural marmoset model of generalized epilepsy, showing genetic predisposition and sensitivity to seizure-inducing agents.

The paper investigates how 3D genome structure influences protein-protein interactions and shows that gene proximity in 3D space correlates with interaction likelihood.

This paper identifies that immuno-positive neoantigens cluster in 3D genome regions and are enriched in active chromosomal compartments, suggesting 3D genome information can improve neoantigen prioritization.