Christine R. Rose

The role of the glutamate-glutamine cycle in synaptic transmission during ischemia and recovery

This study develops a biophysical model of the glutamate-glutamine cycle during ischemia, showing that synaptic failure is due to EAAT dysfunction and sodium gradient collapse, not glutamate release or glutamine synthetase.

Local differences in baseline sodium shape astrocytic potassium uptake by the NKA

The paper quantifies astrocytic sodium concentrations in mouse brain tissue and finds subcellular and cellular heterogeneity in [Na+] and NKA-mediated potassium uptake.

Spatio-temporal dynamics of lateral Na+ diffusion in apical dendrites of mouse CA1 pyramidal neurons

This study investigates the spatio-temporal dynamics of Na+ diffusion in dendrites of mouse CA1 pyramidal neurons using imaging and simulations, finding that normal diffusion rapidly clears local Na+ transients.

Atypical plume-like events drive glutamate accumulation in metabolic stress conditions

The paper uses fluorescent glutamate sensors to show that plume-like glutamate release events increase under metabolic stress, contributing to glutamate accumulation and excitotoxicity.

A Deep Learning-Based Segmentation of Cells and Analysis (DL-SCAN)

DL-SCAN automates cell segmentation and analysis in fluorescence microscopy images, improving consistency and reducing user bias in ion dynamics studies.

Deep learning-driven neuromorphogenesis screenings identify repurposable drugs for mitochondrial disease

The paper identifies repurposable drugs for mitochondrial disease by using deep learning to screen for compounds that improve neuronal commitment and neurogenesis in Leigh syndrome organoids.

Cerebrospinal fluid formation is controlled by membrane transporters to modulate intracranial pressure

This study identifies membrane transporters involved in cerebrospinal fluid (CSF) secretion and shows their role in modulating intracranial pressure.

Novel algorithms for improved detection and analysis of fluorescent signal fluctuations

The paper introduces two algorithms for detecting and analyzing fluorescent signal fluctuations, along with an interactive tool for their application.

Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus

This study shows acetazolamide reduces intracranial pressure directly by acting on the choroid plexus in rats, without relying on systemic effects.

On the Origin of Ultraslow Spontaneous Na+ Fluctuations in Neurons of the Neonatal Forebrain

This study identifies ultraslow Na+ fluctuations in neonatal hippocampal neurons and astrocytes, showing they are driven by GABAergic inhibition and vulnerable to hyperactivity.

Local postsynaptic signalling on slow time scales in reciprocal olfactory bulb granule cell spines matches asynchronous release

The paper investigates slow postsynaptic signaling in olfactory bulb granule cell spines and shows it enables asynchronous GABA release through multiple local mechanisms.