Marcella van Hoolwerff

Dynamic suspension culture enhances scalable maturation of hiPSC-derived cartilage organoids for regenerative medicine

This paper develops a dynamic suspension culture system to improve the maturation of hiPSC-derived cartilage organoids, showing enhanced ECM deposition and gene expression compared to static culture.

Nuclear Factor I genes drive chondrogenic cell-fate commitment

The paper maps chondrogenic cell-fate trajectories in hiPSCs using scRNA-seq and scATAC-seq, identifying NFIA and NFIB as key regulators driving chondrogenic commitment.

RNA sequencing reveals interacting key determinants of osteoarthritis acting in subchondral bone and articular cartilage.

The paper identifies differentially expressed genes in OA subchondral bone and cartilage using RNA sequencing, highlighting IL11 and CHADL as potential druggable targets.

Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional cis-acting long non-coding RNAs and their targets in articular cartilage

The paper identifies differentially expressed lncRNAs in OA cartilage and validates their regulatory role on adjacent genes.