Author

Tamina Kienka

Broad InstituteORCID 0000-0003-1551-0057Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:perturbation response prediction· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Marcela Valderrama MausiD· 2 shared Nelson H. KnudseniD· 2 shared Robert T. MangusoiD· 2 shared Adam Samuel SperlingiD· 1 shared Alexander ArmstrongiD· 1 shared Alexánder RojasiD· 1 shared Amanda A. BouffardiD· 1 shared Andi Cheng· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersSynthetic Biology

Marcela Valderrama MausORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 1, 2026

A Lenalidomide-Inducible Suicide Switch for Gene- and Cell-Based Therapy

Ditsa Sarkar, William Lin, Nelson H. Knudsen…·Max Jan

This paper introduces a lenalidomide-inducible suicide switch for gene- and cell-based therapies that enables safe and effective cell depletion without detectable leakiness.

DOI 10.64898/2026.09.30.755642

humanexperimental assay

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ImmunologyNaturePeer-reviewedSep 24, 2025

In vivo CRISPR screens identify key modifiers of CAR T cell function in myeloma

Nelson H. Knudsen, Giulia Escobar, Felix Korell…·Marcela Valderrama Maus

The paper uses in vivo CRISPR screens to identify genes affecting CAR T cell persistence and function in multiple myeloma, finding CDKN1B as a key regulator of late-stage CAR T cell fitness.

50 citationstop 1%

humangenetic perturbation / CRISPR

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