Adam Samuel Sperling

This paper introduces a lenalidomide-inducible suicide switch for gene- and cell-based therapies that enables safe and effective cell depletion without detectable leakiness.

This study shows that truncating mutations in PPM1D shift its degradation pathway from ubiquitin-independent to UBR5-mediated, leading to increased PPM1D levels and oncogenic effects.

This study identifies new PPM1D inhibitors using a drug discovery platform and shows their distinct biological effects compared to other DDR and p53 pathway modulators.

This study uses dry mass and volume measurements to assess early response of multiple myeloma cells to proteotoxic and genotoxic treatments, finding dry mass increases correlate with bortezomib sensitivity.

The paper identifies widespread intronic polyadenylation (IpA) events in immune cells and shows their role in transcriptome diversification and potential functional consequences.