Mylène Bohec

Spatial and Bulk Transcriptomic Profiling Defines the Molecular Evolution of Cutaneous Squamous Cell Carcinoma and Reveals Stage-Specific Biomarkers of Clinical Relevance

This study uses spatial and bulk transcriptomics to map cSCC progression, identifies stage-specific gene programs, and finds prognostic biomarkers relevant across cancers.

Myeloid reprogramming by poly(I:C) recruits progenitor-exhausted CD8+ T cells and sensitizes rhabdoid tumors to PD-1 blockade

This study shows that poly(I:C) reprograms myeloid cells in rhabdoid tumors, enhancing CD8+ T cell infiltration and improving response to PD-1 blockade.

Dual PD-L1/TIGIT blockade induces PNAd+ HEV-like vessels and CD62L+ lymphocyte recruitment, driving rhabdoid tumor rejection

This study shows that combining PD-L1 and TIGIT blockade in a mouse model of rhabdoid tumors leads to tumor regression by promoting immune cell recruitment and vascular changes.

Common origin for effector and regulatory Follicular and Tissue-Adapted CD4+ T cells in Non-Small Cell Lung Cancer

The paper identifies a common origin for effector and regulatory CD4+ T cells in non-small cell lung cancer through single-cell analysis, revealing their plasticity and role in immune responses.

Combining population genomics with ancient DNA to understand island colonization history of the Madagascar turtle dove

This study uses modern and ancient DNA data to show that Madagascar turtle doves colonized Mauritius and Reunion independently from Madagascar before human arrival, challenging historical accounts of human-induced demographic collapse.

Radiotherapy triggers pro-angiogenic signaling in human lung

This study uses single-cell RNA sequencing to show that radiotherapy induces pro-angiogenic signaling in human lung tissue, including upregulation of VEGFA and changes in capillary and macrophage populations.

Multi-omics comparison of malignant and normal uveal melanocytes reveals novel molecular features of uveal melanoma.

The paper uses multi-omics analysis to compare malignant and normal uveal melanocytes, identifying genomic instability and a BAP1 promoter deletion as key features of uveal melanoma.

Molecular Underpinnings and Environmental Drivers of Spontaneous Loss of Heterozygosity in Drosophila Intestinal Stem Cells

This study identifies mitotic recombination as the primary mechanism for loss of heterozygosity in Drosophila intestinal stem cells, showing increased LOH frequency with specific bacterial infection.

Kronos scRT: a uniform framework for single-cell replication timing analysis

Kronos scRT enables single-cell replication timing analysis without cell sorting, analyzing thousands of cells from mouse and human cell lines.