Author

Carlos J. Reyes-Sepúlveda

University of Rochester MedicineORCID 0000-0003-1580-3853Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Alison Hobbins· 2 shared Jennetta W. HammondiD· 2 shared John Randolph· 2 shared Julia M. GranatoiD· 2 shared Allison T. RyaniD· 1 shared Angela StoutiD· 1 shared Herman LiiD· 1 shared Nina Silver· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersImmunology

Alison Hobbins

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintApr 3, 2026

Genetic background shapes SEZ6L2 autoimmunity and reveals coordinated immune responses linked to neurological dysfunction

Carlos J. Reyes-Sepúlveda, John Randolph, Julia M. Granato…·Jennetta W. Hammond

This study shows that genetic background affects SEZ6L2 autoimmunity, with SJL mice showing stronger immune responses and neurological dysfunction compared to C57BL/6 mice.

DOI 10.64898/2026.03.31.715689

mouseproteomics

𝕏 PostBluesky

NeuroscienceJournal of NeuroinflammationPeer-reviewedNov 25, 2025

Sez6L2 autoimmunity induces cerebellar ataxia in mice

Carlos J. Reyes-Sepúlveda, Julia M. Granato, John Randolph…·Jennetta W. Hammond

This study shows that Sez6L2 autoimmunity in mice causes cerebellar ataxia, with antibodies and T cells targeting Sez6L2 leading to mobility impairments and brain inflammation.

4 citations

mouseexperimental assay

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