Author

Dong-Hyeok Kwon

Seoul National UniversityORCID 0000-0003-1604-7877Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Beom-Jin Jeon· 2 shared Goo JangiD· 2 shared Dong-Woo KimiD· 1 shared Eun‐Ji KwoniD· 1 shared Hee-Kyoung Kim· 1 shared Hyuk‐Jin ChaiD· 1 shared Hyukjin LeeiD· 1 shared Jeong‐Hwa LeeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersPathology

Beom-Jin Jeon

Mutual co-authors in cluster

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2 papers

Recent·Most cited

PathologyNature CommunicationsPeer-reviewedAug 31, 2026

Mutation-Agnostic Base Editing of the Progerin Farnesylation Site Rescues Hutchinson-Gilford Progeria Syndrome Phenotypes in Neuromuscular Organoids

Dong-Woo Kim, Eun‐Ji Kwon, Beom-Jin Jeon…·Hyuk‐Jin Cha

This paper develops FATE, a mutation-agnostic base-editing platform that rescues HGPS phenotypes in neuromuscular organoids by disrupting the LMNA farnesylation motif.

DOI 10.1038/s41467-026-77251-3

humanexperimental assay

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PhysiologyPLoS ONEPeer-reviewedDec 12, 2025

Shift from visceral to subcutaneous fat in Cyp17a1 knockout rats prevent the progression of metabolic syndrome

Beom-Jin Jeon, Jeong‐Hwa Lee, Dong-Hyeok Kwon…·Goo Jang

This study shows that Cyp17a1 knockout in rats leads to obesity with increased subcutaneous fat, but without metabolic syndrome due to improved subcutaneous fat metabolism.

3 citations

ratbulk RNA-seq

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