Milos Pekny

This study shows that deleting GFAP and Vimentin in astrocytes reduces early synaptic and cognitive dysfunction in Alzheimer's mice by improving protein synthesis and astrocyte function.

This study reveals the helical structure of GFAP filaments in astrocytes using cryo-EM, showing coiled-coil tetramers interdigitate to form a filament tube with functional domains contributing to filament organization and disease pathogenesis.

This study creates spatiotemporal transcriptomic maps of mouse brain after ICH to understand cellular responses and identify therapeutic targets.

This study shows that reactive astrocytes are necessary for promoting beneficial plasticity after ischemic stroke in mice, as their absence leads to impaired recovery and maladaptive connectivity changes.