Author

Mark H. G. Verheijen

Amsterdam NeuroscienceORCID 0000-0002-3739-3755Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

August Benjamin SmitiD· 4 shared Mandy S. J. KateriD· 4 shared Adri A.M. Thomas· 1 shared Adrian NegreaniD· 1 shared Aina Badia‐SoterasiD· 1 shared Aline MakiD· 1 shared Allison M. LakeiD· 1 shared Anikó KőrösiiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersNeuroscience

August Benjamin SmitORCID

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Author profile →

5 papers

Recent·Most cited

Deletion of astrocyte intermediate filaments GFAP and Vimentin enhances protein synthesis and prevents early synaptic and cognitive dysfunction in a mouse model of Alzheimer's disease

Cristina Boers-Escuder, Mandy S. J. Kater, Michiel van der Zwan, Yvonne Gouwenberg, Remco V. Klaassen, Christiaan F. M. Huffels, Milos Pekny, Elly M. Hol, August Benjamin Smit, Mark H. G. Verheijen

This study shows that deleting GFAP and Vimentin in astrocytes reduces early synaptic and cognitive dysfunction in Alzheimer's mice by improving protein synthesis and astrocyte function.

bioRxiv · Mar 25, 2026 · PreprintNeuroscience

Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer's disease: age- and pathology-dependent effects on mitochondrial proteins

Janssen M. Kotah, Mandy S. J. Kater, Niek Brosens, Sylvie L. Lesuis, Roberta Tandari, Thomas M. Blok, Luca Marchetto, Ella Yusaf, Frank Koopmans, August Benjamin Smit, Paul John Lucassen, Harm J. Krugers, Mark H. G. Verheijen, Anikó Kőrösi

This study examines how early-life stress affects the synaptic proteome in Alzheimer's disease mouse models, revealing age- and pathology-dependent changes in mitochondrial and astrocytic proteins.

Alzheimer s & Dementia · Dec 6, 2023Peer-reviewedNeuroscience

Proximity of astrocyte leaflets to the synapse determines memory strength

Aina Badia‐Soteras, Tim S. Heistek, Mandy S. J. Kater, Aline Mak, Adrian Negrean, Michel C. van den Oever, Huibert D. Mansvelder, Baljit S. Khakh, Rogier Min, August Benjamin Smit, Mark H. G. Verheijen

This study shows that astrocyte leaflet structure, regulated by Ezrin, affects memory strength by controlling glutamate diffusion and synaptic function in the hippocampus.

Biological Psychiatry · Oct 29, 2022Peer-reviewedNeuroscience

Activity dependent translation in astrocytes dynamically alters the proteome of the perisynaptic astrocyte process

Darshan Sapkota, Mandy S. J. Kater, Kristina Sakers, Kayla R. Nygaard, Y. Liu, Allison M. Lake, Rohan Khazanchi, Rana R. Khankan, August Benjamin Smit, Susan E. Maloney, Mark H. G. Verheijen, Y. Zhang, Joseph D. Dougherty

The paper shows astrocytes have a translational response to neuronal activity, altering their proteome at synapses through BDNF and K+ signals.

bioRxiv · Apr 8, 2020 · PreprintNeuroscience

Integrated Stress Response Deregulation underlies Vanishing White Matter and is a target for therapy

Truus E. M. Abbink, Lisanne E. Wisse, Ermelinda Jaku, Michiel J. Thiecke, Daniel Voltolini‐González, Hein Fritsen, Sander Bobeldijk, Timo J. ter Braak, Emiel Polder, Nienke L. Postma, Marianna Bugiani, Eduard A. Struijs, Mark H. G. Verheijen, Nina Straat, Sophie van der Sluis, , Marjo S. van der Knaap

ISRIB ameliorates ISR deregulation and clinical signs in VWM mice.

bioRxiv · Dec 4, 2018 · PreprintNeuroscience