Author

Kasirajan Ayyanathan

University of PennsylvaniaORCID 0000-0003-1643-4009Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:non-human primate· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Ashwin N. SkellyiD· 3 shared Beatrice H. HahniD· 3 shared George M. ShawiD· 3 shared John W. CareyiD· 3 shared Rumi HabibiD· 3 shared Ajay Veer SinghiD· 2 shared Andrew Jesse ConnelliD· 2 shared Barton F. HaynesiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Ashwin N. SkellyORCID

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3 papers

Recent·Most cited

ImmunologyProceedings of the National Academy of SciencesPeer-reviewedApr 29, 2026

Deep Mining of the Human Antibody Repertoire Identifies Frequent and Genetically Diverse CDRH3 Topologies Targetable by Vaccination

Rumi Habib, Shahlo O. Solieva, Zi Jie Lin…·Daniel W. Kulp

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

8 citationstop 3%

humanproteomics

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ImmunologybioRxivPreprintOct 6, 2025

Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design

Ashwin N. Skelly, Harry B. Gristick, Hui Li…·George M. Shaw

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

3 citations

non-human primateexperimental assay

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ImmunologybioRxivPreprintMay 3, 2025

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development

Rumi Habib, Ryan S. Roark, Hui Li…·George M. Shaw

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

8 citations

ratproteomics

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