Daniel W. Kulp

The paper identifies frequent and genetically diverse CDRH3 topologies in the human antibody repertoire that can be targeted by vaccination to elicit broadly neutralizing antibodies.

The paper designs a multi-epitope immunogen for malaria using machine learning, demonstrating its ability to bind and orient three copies of the L9 antibody.

This paper introduces WIN332, an engineered immunogen that elicits N332-glycan-independent V3-glycan antibodies in nonhuman primates after a single immunization.

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

This study shows that transient glycan deletions in SHIVs can induce CD4-binding site broadly neutralizing antibodies in macaques, offering a model for HIV vaccine design.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

This study identifies ArlI, ArlJ, and CirA as regulators of pilin-mediated motility in Haloferax volcanii through genetic and expression analyses.

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

This paper expands the Rosetta software suite with tools for glycan modeling, density fitting, and rational sequon design, achieving high accuracy in predicting and building glycan structures.