Kaoru Saijo

This paper creates a PTHS mouse model with astrocyte-specific Tcf4 knockout, showing seizures, astrogliosis, increased neuronal activity, and gene expression changes.

The paper investigates how copper levels affect microglial inflammation, finding that both excess and deficiency disrupt immune responses to LPS.

This study shows microglia regulate sleep through Gi-coupled signaling, Ca2+ signaling, and suppression of norepinephrine transmission.

This study shows that TLR3-mediated maternal immune activation induces specific behavioral changes in mouse offspring through fetal innate immunity.

This study shows Phf15 represses pro-inflammatory genes and antiviral responses in microglia, regulating inflammation during aging and LPS stimulation.

The paper shows that defective microglial pyroptosis in mice leads to ADHD-like behaviors, suggesting a link between microglial cell death and neurodevelopmental disorders.