Yang Dan

Age-related changes in behavioural and neural variability in a decision-making task

This study examines age-related changes in neural and behavioural variability during a decision-making task in mice, finding increased neural variability and reduced variability quenching in specific brain regions.

Brainstem circuit for sickness-induced sleep

The paper identifies a brainstem circuit involving the nucleus of the solitary tract and parabrachial nucleus that mediates sickness-induced sleep by reducing norepinephrine release.

Brain-wide representations of prior information in mouse decision-making

Mice infer stimulus-side priors from recent choices; prior signals are decodable pre-stimulus in 24.0% to 30.2% of 242 brain regions, including early visual and motor areas.

A Brain-Wide Map of Neural Activity during Complex Behaviour

The paper presents a brain-wide neural activity map from 621,733 neurons across 139 mice performing a decision-making task, showing how neural activity encodes task variables across brain regions.

A common computational and neural anomaly across mouse models of autism

The paper shows that mice with ASD-related mutations exhibit similar computational and neural anomalies in prior updating during decision-making.

Activation of locus coeruleus noradrenergic neuronsrapidly drives homeostatic sleep pressure

The paper shows that activating locus coeruleus noradrenergic neurons increases sleep propensity after wakefulness, indicating their role in sleep pressure through functional fatigue.

Restoration of locus coeruleus noradrenergic transmission during sleep

The paper shows that noradrenaline transmission from the locus coeruleus decreases with wakefulness and recovers during sleep, with mTOR signaling involved in recovery.

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling, and cloud-native open-source tools

Microglia Regulate Sleep via Calcium-Dependent Modulation of Norepinephrine Transmission

This study shows microglia regulate sleep through Gi-coupled signaling, Ca2+ signaling, and suppression of norepinephrine transmission.

Data architecture for a large-scale neuroscience collaboration

The paper describes a modular data architecture for a neuroscience collaboration, enabling data contribution, access, and analysis across multiple labs.

Database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging data

The paper introduces a database and deep learning tool for spike inference from calcium imaging data, outperforming existing methods with an automated, parameter-free algorithm.

Standardized and reproducible measurement of decision-making in mice

This paper develops a standardized task for measuring decision-making in mice, showing reproducible results across multiple laboratories and providing a public dataset and tools.

Robust, automated sleep scoring by a compact neural network with distributional shift correction

This paper introduces a compact neural network with mixture z-scoring to automate sleep scoring, showing it avoids systematic bias present in standard methods.

Sleep and Motor Control by a Basal Ganglia Circuit

This study identifies a basal ganglia circuit involving SNr and STN neurons that regulates sleep and motor control by modulating behavioral transitions.