Anan Li

Connecting single neuron transcriptomes to the projectome in mouse visual cortex

The paper integrates transcriptomic, morphological, and electrophysiological data to define neuron types in mouse visual cortex and predict their projection targets.

Motor Cortex Modulates Ipsilateral Limb Movement Through a Direct Cortico-Cerebellar Circuit

The paper identifies a cortico-cerebellar pathway that modulates ipsilateral limb movement, showing its role in initiation and coordination without affecting contralateral movement.

Integrated Classification of Cortical Cells and Quantitative Projectomic Mapping Unveil Organizational Principles of Brain-Wide Connectomes at Single Cell Level

This study integrates molecular and morphological data to classify cortical neurons and map their connectomes, revealing organizational principles of brain-wide networks at the single-cell level.

Sharing Massive Biomedical Data at Magnitudes Lower Bandwidth Using Implicit Neural Function

This paper introduces BRIEF, a method for compressing biomedical data with high fidelity and low bandwidth, enabling efficient sharing and downstream analysis.

Microglia Regulate Sleep via Calcium-Dependent Modulation of Norepinephrine Transmission

This study shows microglia regulate sleep through Gi-coupled signaling, Ca2+ signaling, and suppression of norepinephrine transmission.

Projectome-defined subtypes and modular intra-hypothalamic subnetworks of peptidergic neurons

The paper identifies 31 projectome-defined subtypes of hypothalamic neurons and six modular subnetworks, revealing the organization of axon projections and their functional roles.

Simultaneously cholinergic projection in Ascending and Descending Circuits from Midbrain

The paper characterizes the organization of midbrain cholinergic neurons by reconstructing their axonal projections and identifying distinct subtypes based on their connectivity patterns.

MorphoGNN: Morphological Embedding for Single Neuron with Graph Neural Networks

The paper introduces MorphoGNN, a graph neural network method for embedding single neuron morphology, achieving competitive performance in classification and retrieval tasks.

Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in mouse dorsal and median raphe nucleus

The paper creates a whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nucleus, revealing distinct projection patterns and input sources.

The mouse cortico-basal ganglia-thalamic network

The paper maps functional domains and subnetworks in the cortico-basal ganglia-thalamic loop in mice, revealing complex patterns of convergence and divergence.

Cellular Anatomy of the Mouse Primary Motor Cortex

The paper provides a detailed cellular-resolution map of the mouse primary motor cortex, defining cell types and their connectivity.

Reconstruction of the Hypothalamo-Neurohypophysial System and Functional Dissection of Magnocellular Oxytocin Neurons in the Brain

This study reconstructs the hypothalamo-neurohypophysial system's structure and function, revealing MNCs' role in both peripheral and central oxytocin actions.

Brain-wide single neuron reconstruction reveals morphological diversity in molecularly defined striatal, thalamic, cortical and claustral neuron types

Complete morphologies of 1,708 neurons, sparsely labelled and imaged whole-brain with fMOST, expose region-specific long-range projection rules and finer diversity than current transcriptomic subtypes capture.

Visualizing dendritic characteristics of corticotropin-releasing hormone neurons at single-cell resolution in the whole mouse brain

The paper characterizes the dendritic morphology of CRH neurons across the mouse brain using fMOST, revealing regional differences and specific structural features.

Highly efficient and super-bright neurocircuit tracing using vector mixing-based virus cocktail

This paper introduces MAP-ENVIVIDERS, a vector mixing-based virus cocktail that significantly improves neurocircuit tracing efficiency and sensitivity compared to existing methods.

A robust image registration interface for large volume brain atlas

This paper introduces BrainsMapi, a robust image registration interface for large volume brain datasets, achieving accurate registration of cellular-level data up to 20 TB.

Serotonin Neurons in the Dorsal and Medial Raphe Nuclei: from Single-Cell Transcriptomes to Whole-Brain Projections

The paper characterizes serotonin neuron subtypes in the dorsal and medial raphe nuclei using single-cell RNA sequencing and maps their axonal projections to understand their functional diversity.

Dense reconstruction of brain-wide neuronal population close to the ground truth

The paper develops a tool for fast and accurate reconstruction of neuronal populations in large brain datasets, achieving results close to ground truth with high automation.

Identifying weak signals in inhomogeneous neuronal images for large-scale tracing of neurites

This paper introduces ST-LFV, a method that improves weak signal identification in neuronal images, achieving higher recall and precision than existing tools for large-scale neurite tracing.