Daniel Silverman

The paper identifies a brainstem circuit involving the nucleus of the solitary tract and parabrachial nucleus that mediates sickness-induced sleep by reducing norepinephrine release.

The paper shows that activating locus coeruleus noradrenergic neurons increases sleep propensity after wakefulness, indicating their role in sleep pressure through functional fatigue.

The paper shows that noradrenaline transmission from the locus coeruleus decreases with wakefulness and recovers during sleep, with mTOR signaling involved in recovery.

This study shows microglia regulate sleep through Gi-coupled signaling, Ca2+ signaling, and suppression of norepinephrine transmission.