Developmental rewiring of EHMT1 function during human cortical neurogenesis
Kritika Kasliwal, Kaushiki Chatterjee, Vittoria Dickinson Bocchi, Syed Raza Mahmood, Christopher M. Uyehara, William Marchese, Alejandra Laguillo-Diego, Emily Goetzler, Gabriel Theis, Andrew P. Minotti, Ryan M Walsh, Alexander Polyzos, Effie Apostolou, Simone Sidoli, Lorenz Studer, Matthias Stadtfeld
This study shows EHMT1's functional rewiring during human cortical neurogenesis, revealing its shift from restraining pluripotency to supporting neuronal programs and its resilience to prolonged depletion.
bioRxiv · Oct 12, 2026 · PreprintDevelopmental Biology